個人簡介：
? ? ? ?現(xiàn)任中山大學附屬第七醫(yī)院副研究員，碩士生導師，中山大學高層次引進人才。于2016年獲得南方醫(yī)科大學病理生理學專業(yè)博士。曾于2013-2017年在美國University of Pittsburgh外科學系先后任Visiting Scholar和Research Associate，并于2017-2020年在美國Johns Hopkins University神經(jīng)學系任博士后。目前主要研究方向包括：1、細胞外囊泡調控阿爾茲海默癥的發(fā)生發(fā)展機制研究；2、神經(jīng)退行性疾病中，細胞外囊泡與細胞死亡在其中發(fā)揮作用的分子機制研究；3、發(fā)掘以細胞外囊泡為載體的相關疾病的新型生物標記物。以第一作者/通訊作者發(fā)表SCI論文14篇，包括Journal of Extracellular Vesicles, Cell Communication and Signaling, Ageing Research Reviews, Cell Death & Differentiation, Clinical and Translational Medicine等國際知名學術期刊。曾榮獲國際細胞外囊泡協(xié)會2019年會的青年研究員獎（ISEV2019 Young Investigator Award）。目前主持國家自然科學基金青年項目、廣東省自然面上項目、深圳市科創(chuàng)委面上項目等。
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教育背景：
2011.09－2016.07，南方醫(yī)科大學，病理生理學，博士?
2006.09－2011.07，廣州中醫(yī)藥大學，中醫(yī)學，學士
研究工作經(jīng)歷：
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2020.11－至今，中山大學附屬第七醫(yī)院，科研中心，副研究員
2017.11－2020.10，Johns Hopkins University，Post-Doctoral Fellow??????
2015.10－2017.10，University of Pittsburgh，Research Associate????????
2013.05－2015.09，University of Pittsburgh，Visiting Scholar??????????
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研究方向：
1、細胞外囊泡調控阿爾茲海默癥的發(fā)生發(fā)展機制研究
2、神經(jīng)退行性疾病中，細胞外囊泡與細胞死亡在其中發(fā)揮作用的分子機制研究
3、發(fā)掘以細胞外囊泡為載體的相關疾病的新型生物標記物
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科研論文：
1. Sitong Liu*, Aitong Feng*, Zhigang Li#. Neuron-Derived Extracellular Vesicles: Emerging Regulators in Central Nervous System Disease Progression. Molecular Neurobiology. 2025 May 6. doi: 10.1007/s12035-025-05010-4.
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2. Yongbing Qian*, Xiaoning Hong*, Yang Yu*, Cong Du*, Jing Li, Jiaying Yu, Wenjun Xiao, Chen Chen, Defa Huang, Tianyu Zhong, Jiang Li, Xi Xiang#, Zhigang Li#. Characterization and functional analysis of eccDNA discovered from circulating extracellular vesicles in liver failure. Clinical and Translational Medicine. 2024 Oct;14(10):e70059. doi: 10.1002/ctm2.70059.
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3. Yi Zhou*, Chuhan Na*, Zhigang Li#. Novel insights into immune cells modulation of tumor resistance. Critical Reviews in Oncology/Hematology. 2024 Jul 20:202:104457. doi: 10.1016/j.critrevonc.2024.104457.
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4. Zhixin Ma*, Yu Sun*, Yang Yu, Wenjun Xiao, Zhijie Xiao, Tianyu Zhong, Xi Xiang, Zhigang Li#. Extracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis. Cell Communication and Signaling. 2024 May 27;22(1):295. doi: 10.1186/s12964-024-01669-9.
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5. Yang Yu*, Ran Chen*, Kaiyue Mao, Maoyan Deng, Zhigang Li#. The Role of Glial Cells in Synaptic Dysfunction: Insights into Alzheimer's Disease Mechanisms. Aging and Disease 2024 Apr 1;15(2):459-479. doi: 10.14336/AD.2023.0718.
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6. Yu Sun*, Wenjun Xiao*, Yang Yu, Yuchen Jiang, Zhijie Xiao, Defa Huang, Tianyu Zhong, Jiang Li, Xi Xiang, Yulong He#, Zhigang Li#. Colorectal cancer-derived extracellular vesicles containing HSP70 enhance macrophage phagocytosis by up-regulating MARCO expression. Experimental Cell Research 2023 May 15;426(2):113565. doi: 10.1016/j.yexcr.2023.113565.
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7. Biao Li, Zhixin Ma, Zhigang Li#. A novel regulator in Alzheimer's disease progression: The astrocyte-derived extracellular vesicles. Ageing Research Reviews. 2023 Feb 2;86:101871. doi: 10.1016/j.arr.2023.101871.
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8. Siqi Wang*, Jiaxin Sun*, Raha M. Dastgheyb, Zhigang Li#. Tumor-derived extracellular vesicles modulate innate immune responses to affect tumor progression. Frontiers in Immunology, 2022 Nov 2;13:1045624. doi: 10.3389/fimmu.2022.1045624.
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9. Zhigang Li, Mohammed Moniruzzaman, Raha M. Dastgheyb, Seung-Wan Yoo, Meina Wang, Hongbo Hao, Jia Liu, Patrizia Casaccia, Carlos Nogueras-Ortiz, Dimitrios Kapogiannis, Barbara S. Slusher, Norman J. Haughey. Astrocytes deliver CK1 to neurons via extracellular vesicles in response to inflammation promoting the translation and amyloidogenic processing of APP. Journal of Extracellular Vesicles, 2020; 10(2):e12035.
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10. Zhigang Li, Melanie J. Scott, Erica K. Fan, Yuehua Li, Jinghua Liu, Guozhi Xiao, Song Li, Timothy R. Billiar, Mark A. Wilson, Yong Jiang and Jie Fan. Tissue damage negatively regulates LPS-induced macrophage necroptosis. Cell Death & Differentiation. 2016 Sep 1;23(9):1428-47.
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11. Zhigang Li, Erica K. Fan, Jinghua Liu, Melanie J. Scott, Yuehua Li, Song Li, Wen Xie, Timothy R. Billiar, Mark A. Wilson, Yong Jiang, Ping Wang, and Jie Fan. Cold-Inducible RNA-Binding Protein through TLR4 Signaling Induces Mitochondrial DNA Fragmentation and Regulates Macrophage Cell Death after Trauma. Cell Death & Disease. 2017 May 11;8(5):e2775. (2017) 8, e2775; doi:10.1038/cddis.2017.187.
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12. Zhigang Li, Melanie J. Scott, Tomasz Brzóska, Prithu Sundd, Yue-Hua Li, Timothy R. Billiar, Mark A. Wilson, Ping Wang, and Jie Fan. Lung epithelial cell-derived IL-25 negatively regulates LPS-induced exosome release from macrophages. Military Medical Research. 2018 Jul 30;5(1):24. doi: 10.1186/s40779-018-0173-6.
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13. Zhigang Li, Yang Jiao, Erica K. Fan, Melanie J. Scott, Yuehua Li, Song Li, Timothy R. Billiar, Mark A. Wilson, Xueyin Shi, and Jie Fan. Aging-Impaired Filamentous Actin Polymerization Signaling Reduces Alveolar Macrophage Phagocytosis of Bacteria. The Journal of Immunology. 2017 Nov 1;199(9):3176-3186.?
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14. Yang Jiao*, Zhigang Li*, Patricia A. Loughran, Erica K. Fan, Melanie J. Scott, Yuehua Li, Timothy R. Billiar, Mark A. Wilson, Xueyin Shi, and Jie Fan. Frontline Science: Macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock. Journal of Leukocyte Biology. 2018 Feb;103(2):175-183. (*co-first author).
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